Description
Decivac® FMD DOE is an inactivated oil adjuvanted vaccine for the active immunisation of pigs, cattle, buffalo, sheep and goats against Foot and Mouth Disease.

Composition
Decivac® FMD DOE may contain a mix of antigens of the FMDV types O, A, C, Asia1 and SAT1, SAT2, SAT3 (monovalent or multivalent). The actual combination of antigens depends on the local situation. Each dose (2 ml) of vaccine contains at least 3 PD50 of the virus types indicated (Ph. Eur.). The FMD viruses are propagated on BHK cells, inactivated by binary ethylene imine and subsequently purified and concentrated by precipitation with polyethylene glycol. The resulting antigens are stored at ultra low temperature until formulation of the final vaccine.

Formulation
Double oil emulsion (DOE)

Indications
For the vaccination of cattle, buffalo, sheep, goats and pigs to protect against clinical Foot and Mouth Disease, and/or as part of a disease eradication programme.

Vaccination
Pigs:

• young animals without maternal antibodies: primary vaccination from two weeks of age onwards*, followed by revaccination 4-6 months later.
• young animals with, or suspected of having, maternal antibodies: primary vaccination from 4-8 weeks of age onwards*, followed by revaccination 4-6 months later.
• adult animals: every 4-6 months.  

Cattle, Buffalo:

• young animals without maternal antibodies: primary vaccination from two weeks of age onwards, followed by revaccination 4-6 months later.
• young animals with, or suspected of having, maternal antibodies: primary vaccination from 4 months of age onwards, followed by revaccination 4-6 months later.  
• adult animals: every 6 months.  

Sheep, Goats:

• young animals without maternal antibodies: primary vaccination from two weeks of age onwards, followed by revaccination 4-6 months later.
• young animals with, or suspected of having, maternal antibodies: primary vaccination from 2 months of age onwards, followed by revaccination 4-6 months later. 
• adult animals: every 6 months.  

*In areas where FMD is endemic, a booster vaccination is recommended 6 weeks after the primary vaccination.

Dosage
Cattle, buffalo, pigs:
2 ml.
 
Sheep, goats:
1 ml.
 
Method of administration
Cattle, buffalo:  subcutaneous or intramuscular (e.g. in the dewlap or neck)
Sheep, goats:  subcutaneous or intramuscular (e.g. behind the elbow or in the neck)
Pigs:  intramuscular (in the neck)
 
Withholding period
Nil

Presentation
50, 100 or 250 ml polyethylene-terephthalate (PET) vials closed with a rubber stopper and sealed with an aluminium cap.

Storage
Store at a temperature of  2-8°C, protected from light. Do not freeze.

Further information
A transient swelling may occur at the site of injection. Immunity will develop as early as 10 days after vaccination and will last for about 6 months in cattle, buffalo, sheep and goats, about 4 months in pigs; in regularly vaccinated animals, even longer.

Precautions
Shake before use. 

GENERAL REMINDER
Usage instructions and withdrawal periods may vary by country. Always follow label instructions and consult your veterinarian.